Product overview

Name Amlodipine besylate
Alternative names Norvasc
Purity >99%
Description L-type calcium channel blocker
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Biological Data

Biological description L-type calcium channel blocker. Decreases eNOS expression in the aorta. Shows antiproliferative, antihypertensive, antioxidant, anti-inflammatory, vasoprotective and neuroprotective actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (10mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarbo xylic acid 3-ethyl 5-methyl ester benzenesulfonate
Molecular Weight 567.05
Chemical structure Amlodipine besylate  [111470-99-6] Chemical Structure
Molecular Formula C20H25ClN2O5.C6H6O3S
CAS Number 111470-99-6
PubChem identifier 60496
SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
InChi InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChiKey ZPBWCRDSRKPIDG-UHFFFAOYSA-N
MDL number MFCD00887594

References for Amlodipine besylate

References are publications that support the biological activity of the product
  • Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells.

    Choi NY et al (2014) Brain Res 1551 : 1-12.
  • Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta

    Toba H et al (2005) Hypertens Res 28(8) : 689-700.
  • Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta

    Toba H et al (2005) Hypertens Res 28(8) : 689-700.
  • Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells.

    Yoshida J et al (2003) Eur J Pharmacol 472(1-2) : 23-31.

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