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AMG 9810

(HB1188)
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Product overview

Name AMG 9810
Purity >98%
Description Potent, selective, competitive TRPV1 channel antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Potent, selective and competitive TRPV1 channel antagonist (IC50 values are 24.5 and 85.6 nM for human and rat TRPV1 respectively). Competitively inhibits capsaicin binding to rat TRPV1. Displays antihyperalgesic effects.

Solubility & Handling

Solubility overview Soluble in DMSO (50mM) or ethanol (100mM)
Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide
Molecular Weight 337.42
Chemical structure AMG 9810 [545395-94-6] Chemical Structure
Molecular Formula C21H23NO3
CAS Number 545395-94-6
PubChem identifier 680502
SMILES CC(C)(C)C1=CC=C(C=C1)\C=C\C(=O)NC1=CC=C2OCCOC2=C1
InChiKey GZTFUVZVLYUPRG-IZZDOVSWSA-N

References for AMG 9810

References are publications that support the biological activity of the product

  • Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis.

    Hu Y et al (2014) Am J Physiol Gastrointest Liver Physiol 307(2) : G149-57.
    Read more (PubMedID: 24875100)

  • No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex.

    Liu MG et al (2014) Mol Brain 7 : 27
    Read more (PubMedID: 24708859)

  • AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.

    Gavva NR et al (2005) J Pharmacol Exp Ther 313(1) : 474-84.
    Read more (PubMedID: 15615864)

3 Item(s)

Grouped product items
Order: HB1188
Pack PriceQty
10mg
$165
50mg
$656
Potent, selective, competitive TRPV1 channel antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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