Product overview

Purity >98%
Description Potent, selective GluK1 (GluR5) kainate receptor antagonist
Write Your Own Review
You're reviewing:ACET
Rate this item:

Biological Data

Biological description Potent and selective GluK1 (GluR5) kainate receptor antagonist (Kb = 1.4 nM). Ineffective at GluK2, GluK3 and mGluR 6 and 7 receptors. Blocks NMDA receptor -independent long term potentiation induction.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Purity >98%
Chemical name (S)-1-(2-Amino-2-carboxyethyl)-3-(2 -carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
Molecular Weight 429.45
Chemical structure ACET  [936095-50-0] Chemical Structure
Molecular Formula C20H19N3O6S
CAS Number 936095-50-0
PubChem identifier 16125102
SMILES O=C(C(C)=CN1C[C@@H](C(O)=O)N)N(CC2=C(C(O)=O)SC(C3=CC=CC=C3)=C2)C1=O

References for ACET

References are publications that support the biological activity of the product
  • Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.

    Duncan GE et al (2012) Brain Res 1443 : 98-105.
  • ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.

    Dargan SL et al (2009) Neuropharmacology 56(1) : 121-30.
  • Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.

    Dolman NP et al (2007) J Med Chem 50(7) : 1558-70.

3 Item(s)