Product overview

Name A 803467
Purity >98%
Description Potent, selective Nav1.8 channel inhibitor
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Biological Data

Biological description Potent and selective voltage-dependent Nav1.8 channel inhibitor (IC50 = 8 nM). Shows >100-fold selectivity over Nav1.3, Nav1.7, Nav1.5 and Nav1.2 channels. Blocks tetrodotoxin resistant currents (IC50 = 140 nM). Shows antinociceptive actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Molecular Weight 357.79
Chemical structure A 803467  [944261-79-4] Chemical Structure
Molecular Formula C19H16ClNO4
CAS Number 944261-79-4
PubChem identifier 16038374
SMILES ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1
InChiKey VHKBTPQDHDSBSP-UHFFFAOYSA-N

References for A 803467

References are publications that support the biological activity of the product
  • Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.

    Tan ZY et al (2014) J Neurosci 34(21) : 7190-7.
  • A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.

    McGaraughty S et al (2008) J Pharmacol Exp Ther 324(3) : 1204-11.
  • A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

    Jarvis MF et al (2007) Proc Natl Acad Sci U S A 104(20) : 8520-5.

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