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Biological Data Biological description Potent and selective voltage-dependent Nav 1.8 channel inhibitor (IC50 = 8 nM). Shows >100-fold selectivity over Nav 1.3, Nav 1.7, Nav 1.5 and Nav 1.2 channels. Blocks tetrodotoxin resistant currents (IC50 = 140 nM). Shows antinociceptive actions.
Solubility & Handling Solubility overview Soluble in DMSO (100mM) or ethanol (25mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 5-(4-Chlorophenyl)-N -(3,5-dimethoxyphenyl)-2-furancarboxamide
Chemical structure
Molecular Formula C19 H16 ClNO4
PubChem identifier 16038374
SMILES ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1
InChiKey VHKBTPQDHDSBSP-UHFFFAOYSA-N
References for A 803467 References are publications that support the biological activity of the product
Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators. Tan ZY et al (2014) J Neurosci 34(21) : 7190-7. A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. McGaraughty S et al (2008) J Pharmacol Exp Ther 324(3) : 1204-11. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Jarvis MF et al (2007) Proc Natl Acad Sci U S A 104(20) : 8520-5.
Potent, selective Nav 1.8 channel inhibitor
![A 803467 [944261-79-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1007.png "A 803467 [944261-79-4]")
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