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Biological Data
| Biological description | Potent and selective voltage-dependent Nav1.8 channel inhibitor (IC50 = 8 nM). Shows >100-fold selectivity over Nav1.3, Nav1.7, Nav1.5 and Nav1.2 channels. Blocks tetrodotoxin resistant currents (IC50 = 140 nM). Shows antinociceptive actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (25mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide |
| Chemical structure | ![A 803467 [944261-79-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "A 803467 [944261-79-4]") |
| Molecular Formula | C19H16ClNO4 |
| PubChem identifier | 16038374 |
| SMILES | ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1 |
| InChiKey | VHKBTPQDHDSBSP-UHFFFAOYSA-N |
References for A 803467
References are publications that support the biological activity of the product
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Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.
Tan ZY et al (2014) J Neurosci 34(21) : 7190-7. -
A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.
McGaraughty S et al (2008) J Pharmacol Exp Ther 324(3) : 1204-11. -
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Jarvis MF et al (2007) Proc Natl Acad Sci U S A 104(20) : 8520-5.
Potent, selective Nav1.8 channel inhibitor
![A 803467 [944261-79-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1007.png "A 803467 [944261-79-4]")
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