Product overview

Name 3-Methyladenine
Description PI-3K inhibitor
Alternative names 3-MA
Purity >99%
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Biological Data

Biological description Phosphoinositide 3-kinase (PI-3K) inhibitor. Inhibits autophagy, modulates endosomal membrane trafficking and stimulates adipocyte PKA-dependent lipolysis. May potentiate the action of anticancer drugs.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 3-Methyl-3H-purin-6-amine
Molecular Weight 149.15
Molecular Formula C6H7N5
CAS Number 5142-23-4
PubChem identifier 1673
SMILES NC(N=CN2C)=C1C2=NC=N1
InChiKey FSASIHFSFGAIJM-UHFFFAOYSA-N

References for 3-Methyladenine

References are publications that support the biological activity of the product
  • 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy.

    Sheng et al (2013) Biochem Biophys Res Commun. 432(1) : 5-9
  • 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN.

    Hirosako et al (2004) Biochem Biophys Res Commun 316(3) : 845-52
  • 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism.

    Caro et al (1988) Eur J Biochem 175(2) : 325-9