Product overview
| Name | 3-Methyladenine |
| Description | PI-3K inhibitor |
| Alternative names | 3-MA |
| Purity | >99% |
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Biological Data
| Biological description | Phosphoinositide 3-kinase (PI-3K) inhibitor. Inhibits autophagy, modulates endosomal membrane trafficking and stimulates adipocyte PKA-dependent lipolysis. May potentiate the action of anticancer drugs. |
Solubility & Handling
| Storage instructions | +4°C |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >99% |
| Chemical name | 3-Methyl-3H-purin-6-amine |
| Molecular Weight | 149.15 |
| Molecular Formula | C6H7N5 |
| CAS Number | 5142-23-4 |
| PubChem identifier | 1673 |
| SMILES | NC(N=CN2C)=C1C2=NC=N1 |
| InChiKey | FSASIHFSFGAIJM-UHFFFAOYSA-N |
References for 3-Methyladenine
References are publications that support the biological activity of the product
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3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy.
Sheng et al (2013) Biochem Biophys Res Commun. 432(1) : 5-9 -
3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN.
Hirosako et al (2004) Biochem Biophys Res Commun 316(3) : 845-52 -
3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism.
Caro et al (1988) Eur J Biochem 175(2) : 325-9
Publications
These publications cite the use of 3-Methyladenine purchased from Hello Bio:
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Characterizing Autophagy in the Cold Ischemic Injury of Small Bowel Grafts: Evidence from Rat Jejunum
Caleb I et al (2021) Metabolites 11(6)PubMedID: 34204418
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