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Biological Data Biological description Phosphoinositide 3-kinase (PI-3K) inhibitor. Inhibits autophagy, modulates endosomal membrane trafficking and stimulates adipocyte PKA-dependent lipolysis. May potentiate the action of anticancer drugs.
Solubility & Handling Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 3-Methyl-3H -purin-6-amine
SMILES NC(N=CN2C)=C1C2=NC=N1
InChiKey FSASIHFSFGAIJM-UHFFFAOYSA-N
References for 3-Methyladenine References are publications that support the biological activity of the product
3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Sheng et al (2013) Biochem Biophys Res Commun. 432(1) : 5-9 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN. Hirosako et al (2004) Biochem Biophys Res Commun 316(3) : 845-52 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism. Caro et al (1988) Eur J Biochem 175(2) : 325-9
Publications
These publications cite the use of 3-Methyladenine purchased from Hello Bio:
Characterizing autophagy in the cold preservation of small bowel grafts Characterizing Autophagy in the Cold Ischemic Injury of Small Bowel Grafts: Evidence from Rat Jejunum Caleb I et al (2021) Metabolites 11(6)
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