GTP cyclohydrolase I (GCH1) inhibitor. Decreases tetrahydrobiopterin (BH4) synthesis and suppresses NOS activity. Also causes a decrease in vascular cell adhesion molecule 1 (VCAM-1) cells in response to TNF-α and IFN-γ.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100 mM), and in water (50 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner.
Ikemoto K et al (2008) Biochim Biophys Acta 1780(7-8) : 960-5.
The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein.
Kolinsky MA et al (2004) J Biol Chem 279(39) : 40677-82.
GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein.
![2,4-Diamino-6-hydroxypyrimidine [56-06-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0070.png "2,4-Diamino-6-hydroxypyrimidine [56-06-4]")
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