Product overview

Name 1-Naphthyl PP1
Description Potent, selective src family kinase inhibitor
Alternative names 1-NA-PP 1
Purity >99%
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Biological Data

Biological description Potent and selective src family kinase inhibitor, including v-Src and c-Fyn. Selective for analogs rather than wild-type kinase (IC50 values are 1.5 nM and 1 µM for v-Src analog versus wild-type). Also inhibits c-AbI and Aurora A kinase and is a potent PKD inhibitor. Shows anti-cancer actions. Cell-permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (20mg/ml) or chloroform
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Molecular Weight 317.39
Chemical structure 1-Naphthyl PP1  [221243-82-9] Chemical Structure
Molecular Formula C19H19N5
CAS Number 221243-82-9
PubChem identifier 4877
SMILES CC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N
InChiKey XSHQBIXMLULFEV-UHFFFAOYSA-N

References for 1-Naphthyl PP1

References are publications that support the biological activity of the product
  • Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.

    Reboutier D et al (2013) J Cell Biol 201(1) : 65-79.
  • New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells.

    Tandon M et al (2013) PLoS One 8(9) : e75601.
  • A chemical switch for inhibitor-sensitive alleles of any protein kinase.

    Bishop AC et al (2000) Nature 407(6802) : 395-401.