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17 β-Estradiol

(HB2494)
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Product overview

Name 17 β-Estradiol
Alternative names Estradiol|E2
Purity >98%
Description Estrogen receptor (ER) agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Estrogen receptor (ER) agonist (Ki values are 0.13 and 0.12 nM at ERα and ERβ respectively). Also shows activity at GPR30 receptors (Ki = 6 nM). Endogenous hormone. Shows neuroprotective and antioxidant effects.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM) and in ethanol (75 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Molecular Weight 272.38
Chemical structure 17 β-Estradiol [50-28-2] Chemical Structure
Molecular Formula C18H24O2
CAS Number 50-28-2
PubChem identifier 5757
SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
InChi InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChiKey VOXZDWNPVJITMN-ZBRFXRBCSA-N
MDL number MFCD00003693

References for 17 β-Estradiol

References are publications that support the biological activity of the product

  • The ins and outs of GPR30: a transmembrane estrogen receptor.

    Prossnitz ER et al (2008) J Steroid Biochem Mol Biol 109(3-5) : 350-3.
    Read more (PubMedID: 18406603)

  • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

    Thomas P et al (2005) Endocrinology 146(2) : 624-32.
    Read more (PubMedID: 15539556)

  • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

    Kuiper GG et al (1997) Endocrinology 138(3) : 863-70.
    Read more (PubMedID: 9048584)

  • 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro.

    Behl C et al (1995) Biochem Biophys Res Commun 216(2) : 473-82.
    Read more (PubMedID: 7488136)

4 Item(s)

Grouped product items
Order: HB2494
Pack PriceQty
100mg
$53
Estrogen receptor (ER) agonist
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Hazardous: $35

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