Product overview
Name | 17 α-Estradiol |
Description | Estrogen receptor (ER) ligand. |
Alternative names | Estradiol|Alfatradiol|EST |
Purity | >96% |
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Biological Data
Biological description | Endogenous estrogen receptor (ER) ligand (Ki values are 0.2 and 1.2 nM at ERα and ERβ respectively). Shows antioxidant, anti-neurodegenerative and neuroprotective effects. This is a research use only product, exclusively for biomedical research use at verified research organizations. It is not intended for human or veterinary use. |
Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in DMSO (100 mM), and in ethanol (100 mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | (17α)-Estra-1,3,5(10)-triene-3,17-diol |
Molecular Weight | 272.38 |
Chemical structure | |
Molecular Formula | C18H24O2 |
CAS Number | 57-91-0 |
PubChem identifier | 68570 |
SMILES | [H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@H]4O |
InChi | InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1 |
InChiKey | VOXZDWNPVJITMN-SFFUCWETSA-N |
MDL number | MFCD00064144 |
Appearance | White solid |
References for 17 α-Estradiol
References are publications that support the biological activity of the product
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Acarbose, 17-?±-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.
Harrison DE et al (2014) Aging Cell 13(2) : 273-82. -
Effects of 17 beta-estradiol and its isomer 17 alpha-estradiol on learning in rats with chronic cholinergic deficiency in the brain.
Lermontova NN et al (2000) Bull Exp Biol Med 129(5) : 442-4. -
17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells.
Green PS et al (1997) J Neurosci 17(2) : 511-5. -
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.
Kuiper GG et al (1997) Endocrinology 138(3) : 863-70.