Product overview

Name 17 α-Estradiol
Alternative names Estradiol|Alfatradiol|EST
Purity >98%

Estrogen receptor (ER) ligand.

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Biological Data

Biological description

Endogenous estrogen receptor (ER) ligand (Ki values are 0.2 and 1.2 nM at ERα and ERβ respectively). Shows antioxidant, anti-neurodegenerative and neuroprotective effects.

This is a research use only product, exclusively for biomedical research use at verified research organizations. It is not intended for human or veterinary use.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM), and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (17α)-Estra-1,3,5(10)-triene-3,17-diol
Molecular Weight 272.38
Chemical structure 17 α-Estradiol Chemical Structure
Molecular Formula C18H24O2
CAS Number 57-91-0
PubChem identifier 68570
SMILES [H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@H]4O
InChi InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
MDL number MFCD00064144
Appearance White solid

References for 17 α-Estradiol

References are publications that support the biological activity of the product
  • Acarbose, 17-?±-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.

    Harrison DE et al (2014) Aging Cell 13(2) : 273-82.
  • Effects of 17 beta-estradiol and its isomer 17 alpha-estradiol on learning in rats with chronic cholinergic deficiency in the brain.

    Lermontova NN et al (2000) Bull Exp Biol Med 129(5) : 442-4.
  • 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells.

    Green PS et al (1997) J Neurosci 17(2) : 511-5.
  • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

    Kuiper GG et al (1997) Endocrinology 138(3) : 863-70.

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