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Biological Data
| Biological description | Endogenous CAMKII inhibitor. Shows many biological actions. Suppresses platelet cyclooxygenase to suppress thromboxane and inhibits platelet activation. Shows neurotoxic actions. |
Solubility & Handling
| Solubility overview | Soluble in water (0.8mg/ml, at 25°C) or DMSO |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid |
| Chemical structure | ![12(S)-HPETE [71774-10-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "12(S)-HPETE [71774-10-2]") |
| Molecular Formula | C20H32O4 |
| PubChem identifier | 656507 |
| SMILES | CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)OO |
References for 12(S)-HPETE
References are publications that support the biological activity of the product
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Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels.
Xie C et al (2011) Endocrinology 152(10) : 3811-9. -
Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons.
Kim SR et al (2008) Br J Pharmacol 155(2) : 253-64. -
12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase.
Brüne B et al (1991) Mol Pharmacol 39(5) : 671-8.
![12(S)-HPETE [71774-10-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0060.png "12(S)-HPETE [71774-10-2]")
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