Product overview

Name 12(S)-HPETE
Purity >98%
Description CaM kinase II inhibitor
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Biological Data

Biological description Endogenous CAMKII inhibitor. Shows many biological actions. Suppresses platelet cyclooxygenase to suppress thromboxane and inhibits platelet activation. Shows neurotoxic actions.

Solubility & Handling

Solubility overview Soluble in water (0.8mg/ml, at 25°C) or DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Molecular Weight 336.5
Chemical structure 12(S)-HPETE  [71774-10-2] Chemical Structure
Molecular Formula C20H32O4
CAS Number 71774-10-2
PubChem identifier 656507
SMILES CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)OO

References for 12(S)-HPETE

References are publications that support the biological activity of the product
  • Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels.

    Xie C et al (2011) Endocrinology 152(10) : 3811-9.
  • Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons.

    Kim SR et al (2008) Br J Pharmacol 155(2) : 253-64.
  • 12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase.

    Brüne B et al (1991) Mol Pharmacol 39(5) : 671-8.

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