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12(S)-HPETE

(HB0060)
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Product overview

Name 12(S)-HPETE
Purity >98%
Description CaM kinase II inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Endogenous CAMKII inhibitor. Shows many biological actions. Suppresses platelet cyclooxygenase to suppress thromboxane and inhibits platelet activation. Shows neurotoxic actions.

Solubility & Handling

Solubility overview Soluble in water (0.8mg/ml, at 25°C) or DMSO
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Molecular Weight 336.5
Chemical structure 12(S)-HPETE [71774-10-2] Chemical Structure
Molecular Formula C20H32O4
CAS Number 71774-10-2
PubChem identifier 656507
SMILES CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)OO

References for 12(S)-HPETE

References are publications that support the biological activity of the product

  • Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels.

    Xie C et al (2011) Endocrinology 152(10) : 3811-9.
    Read more (PubMedID: 21846804)

  • Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons.

    Kim SR et al (2008) Br J Pharmacol 155(2) : 253-64.
    Read more (PubMedID: 18552868)

  • 12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase.

    Brüne B et al (1991) Mol Pharmacol 39(5) : 671-8.
    Read more (PubMedID: 1674588)

3 Item(s)

Grouped product items
Order: HB0060
Pack PriceQty
100μg
$591
CaM kinase II inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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