1-O-Hexadecyl-2-O-acetyl-sn-glycerol

(HB0067)
Technical documents: Datasheet

Product overview

Name 1-O-Hexadecyl-2-O-acetyl-sn-glycerol
Description PKC inhibitor
Purity >98%
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Biological Data

Biological description Protein kinase C (PKC) inhibitor, acts as a diacylglycerol (DAG) antagonist. Synthetic precursor of platelet activating factor (PAF). Shows growth inhibitory actions against the promyelocytic leukemia cell line.

Solubility & Handling

Solubility overview Soluble in ethanol or acetone
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Molecular Weight 358.6
Chemical structure 1-O-Hexadecyl-2-O-acetyl-sn-glycerol  [77133-35-8] Chemical Structure
Molecular Formula C21H42O4
CAS Number 77133-35-8

References for 1-O-Hexadecyl-2-O-acetyl-sn-glycerol

References are publications that support the biological activity of the product
  • Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway.

    Tao J et al (2009) Cell Signal 21(9) : 1436-43.
  • Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.

    Ryan SD et al (2009) Proc Natl Acad Sci U S A 106(49) : 20936-41.
  • 1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells.

    Stoll LL et al (1989) Cell Regul 1(1) : 13-25.
  • 1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells.

    McNamara MJ et al (1984) Biochem Biophys Res Commun 122(2) : 824-30.