Product overview
| Name | 1-O-Hexadecyl-2-O-acetyl-sn-glycerol |
| Description | PKC inhibitor |
| Purity | >98% |
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Biological Data
| Biological description | Protein kinase C (PKC) inhibitor, acts as a diacylglycerol (DAG) antagonist. Synthetic precursor of platelet activating factor (PAF). Shows growth inhibitory actions against the promyelocytic leukemia cell line. |
Solubility & Handling
| Solubility overview | Soluble in ethanol or acetone |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Molecular Weight | 358.6 |
| Chemical structure | ![1-O-Hexadecyl-2-O-acetyl-sn-glycerol [77133-35-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0067.png "1-O-Hexadecyl-2-O-acetyl-sn-glycerol [77133-35-8]") |
| Molecular Formula | C21H42O4 |
| CAS Number | 77133-35-8 |
References for 1-O-Hexadecyl-2-O-acetyl-sn-glycerol
References are publications that support the biological activity of the product
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Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway.
Tao J et al (2009) Cell Signal 21(9) : 1436-43. -
Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.
Ryan SD et al (2009) Proc Natl Acad Sci U S A 106(49) : 20936-41. -
1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells.
Stoll LL et al (1989) Cell Regul 1(1) : 13-25. -
1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells.
McNamara MJ et al (1984) Biochem Biophys Res Commun 122(2) : 824-30.
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