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Biological Data
| Biological description | Potent GABAB receptor agonist. Evokes hyperpolarizations in septal neurones (EC50 = 50 nM). Shows antidepressant actions. Blood-brain barrier permeable. |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3-Aminopropyl(methyl)phosphinic acid |
| Chemical structure | ![SKF 97541 [127729-35-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "SKF 97541 [127729-35-5]") |
| Molecular Formula | C4H12NO2P |
| InChiKey | NHVRIDDXGZPJTJ-UHFFFAOYSA-N |
References for SKF 97541
References are publications that support the biological activity of the product
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Effects of GABAB receptor ligands in animal tests of depression and anxiety.
Frankowska M et al (2007) Pharmacol Rep 59(6) : 645-55. -
Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro.
Bon C et al (1996) Br J Pharmacol 118(4) : 961-7. -
Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices.
Seabrook GR et al (1990) Br J Pharmacol 101(4) : 949-57.
Potent GABAB receptor agonist
![SKF 97541 [127729-35-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0954.png "SKF 97541 [127729-35-5]")
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