Experimental dementia researcher

"The nominee, Naoto Watamura, has made major contributions to the neurodegenerative research community by publishing the following important papers as a graduate student and as a postdoc in my laboratory. 1. Watamura N et al. (2022) Somatostatin-evoked Abeta catabolism in the brain: Mechanistic involvement of alpha-endosulfine-K ATP channel pathway. Mol Psychiatry, 27, 1816–1828 doi: 10.1038/s41380-021-01368-8. 2. Watamura N et al. (2022) An isogenic panel of App knock-in mouse models: profiling beta-secretase inhibition and endosomal abnormalities. Sci Adv, 10;8(23): eabm6155. doi: 10.1126/sciadv.abm6155. 3. Watamura N et al. (2024) The dopaminergic system regulates amyloid-ß dynamics in the brain through neprilysin-mediated proteolytic degradation. Science Signaling, 17(848):eadk1822. doi: 10.1126/scisignal.adk1822. 4. Watamura N et al. (2024) In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds, Nat Neurosci, in press."

Nominated by Takaomi Saido, Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Japan