Product overview

Name 6-Thioguanine
Alternative names 6-TG; Tioguanine
Purity >99%
Description Competitive hypoxanthine-guanine phosphoribosyltransferase substrate
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Biological Data

Biological description Competitive hypoxanthine-guanine phosphoribosyltransferase substrate. An antimetabolite guanine analogue that inhibits DNA methylation. Shows anti-cancer and anti-angiogenic actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name 2-Amino-6-mercaptopurine
Molecular Weight 167.19
Chemical structure 6-Thioguanine  [154-42-7] Chemical Structure
Molecular Formula C5H5N5S
CAS Number 154-42-7
PubChem identifier 2723601
SMILES NC1=NC(S)=C2C(NC=N2)=N1
InChiKey WYWHKKSPHMUBEB-UHFFFAOYSA-N

References for 6-Thioguanine

References are publications that support the biological activity of the product
  • 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

    Wang H et al (2009) Biochemistry 48(10) : 2290-9.
  • Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.

    Elgemeie GH (2003) Curr Pharm Des 9(31) : 2627-42.
  • Anti-angiogenic activity of the purine analog 6-thioguanine.

    Presta M et al (2002) Leukemia 16(8) : 1490-9.

3 Item(s)