Competitive hypoxanthine-guanine phosphoribosyltransferase substrate. An antimetabolite guanine analogue that inhibits DNA methylation. Shows anti-cancer and anti-angiogenic actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.
![6-Thioguanine [154-42-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1379.png "6-Thioguanine [154-42-7]")
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