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Images Saclofen product vial image | Hello Bio
Saclofen product vial image | Hello Bio Biological Data Biological description Selective and competitive GABAB receptor antagonist. Inhibits baclofen binding (IC50 = 7.8 µM).
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (RS )-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Chemical structure
Molecular Formula C9 H12 ClNO3 S
PubChem identifier 122150
SMILES C1=CC(=CC=C1C(CN)CS(=O)(=O)O)Cl
InChi InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
InChiKey JYLNVJYYQQXNEK-UHFFFAOYSA-N
References for Saclofen References are publications that support the biological activity of the product
Proposed antagonists at GABAB receptors that inhibit adenylyl cyclase in cerebellar granule cell cultures of rat. Holopainen I et al (1992) Eur J Pharmacol 227(2) : 225-8. Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists. Drew CA et al (1990) Neurosci Lett 113(1) : 107-10. Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA. Kerr DI et al (1989) Neurosci Lett 107(1-3) : 239-44.
Selective, competitive GABAB receptor antagonist
![Saclofen [125464-42-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0963.png "Saclofen [125464-42-8]")
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