Transporters
Transporters are integral transmembrane proteins involved in the movement of ions, small molecules, peptides, lipids or macromolecules, such as another protein, across a biological membrane. The energy required for active transport processes is obtained by hyrdolyzing ATP or by utilising ion gradients. The three major classes of ATP-driven transporters are: P-type ATPases (eg. Ca2+-ATPases and Na+,K+-ATPases); F-type or V-type ATPases and ATP-binding cassette transporters. The solute carrier family of transporters include the biogenic amine transporters (NET, DAT and SERT) the Na+/H+ exchanger, glutamate transporters (EAAT) and GABA transporters (GAT). Researchers can save up to 50% on transporter blockers and inhibitors from Hello Bio – they are up to half the price of other suppliers and have been reviewed and cited by researchers worldwide.
View transporter products: Cannabinoid | Dopamine | GABA | Glutamate | Glycine | Monoamine | Multidrug Transporter | Na+ / Ca2+ exchangers | Na+ / H+ exchangers | Norepinephrine | Serotonin (5-HT)
A83-01 (HB3218)
Description:Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.
Purity:>98%
5-Azacytidine (HB1374)
Description:DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.
Purity:>98%
CCG 1423 (HB3389)
Description:Rho/SRF pathway inhibitor. Induces intermediate mesoderm differentiation from ESCs.
Purity:>99%
CHIR 99021 (HB1261)
Description:Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.
Purity:>98%
Cyclopamine (HB2965)
Description:Smo and hedgehog (Hh) signaling inhibitor. Also depletes stem like cancer cells and induces hESCs into endocrine cells.
Purity:>98%
DAPT (HB3345)
Description:γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.
Purity:>98%
Dorsomorphin dihydrochloride (HB2800)
Description:Potent, selective AMPK inhibitor. Promotes neural hPSCs differentiation and promotes cardiomyocyte differentiation in mESCs.
Purity:>98%
EHNA hydrochloride (HB3540)
Description:Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.
Purity:>98%
Fluoxetine hydrochloride (HB1600)
Description:Selective 5-HT uptake inhibitor. Affects differentiation of NSCs.
Purity:>98%