G protein coupled receptors

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G-protein-coupled receptors (also known as GPCRs, transmembrane receptors, or 7-TM receptors), are integral membrane proteins that contain seven membrane-spanning domains (helices). They are coupled to heterotrimeric G proteins on the intracellular side of the cell membrane. Ligand binding causes a conformational change in the GPCR, that is then transmitted to the G protein, activating a signal transduction pathway. Researchers can save up to 50% on GPCR receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.

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Items 1-10 of 30

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  1. A83-01 (HB3218)

    2  Reviews
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    Description:

    Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $88
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    Pack:
    25mg
    Price:
    $297
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  2. Description:

    Member of the neurotrophin growth factor family. Plays an important role in synaptic plasticity and neurogenesis.

    Pack:
    2μg
    Price:
    $65
    Qty:
    Pack:
    10μg
    Price:
    $260
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  3. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $48
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    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5×2mg
    Price:
    $180
    Qty:
    Pack:
    10mg
    Price:
    $175
    Qty:
    Pack:
    5mg
    Price:
    $112
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    Pack:
    25mg
    Price:
    $427
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    Pack:
    50mg
    Price:
    $727
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    Pack:
    10mM (1mL in DMSO)
    Price:
    $121
    Qty:
  4. Compound E (HB3849)

    Description:

    Potent, selective, non-competitive γ-secretase inhibitor. Induces neuronal differentiation.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $373
    Qty:
  5. DAPT (HB3345)

    1  Review
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    Description:

    γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    Qty:
    Pack:
    10mg
    Price:
    $168
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    Pack:
    25mg
    Price:
    $418
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    Pack:
    50mg
    Price:
    $703
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $109
    Qty:
  6. Description:

    Potent, selective AMPK inhibitor. Promotes neural hPSCs differentiation and promotes cardiomyocyte differentiation in mESCs.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $200
    Qty:
    Pack:
    50mg
    Price:
    $795
    Qty:
  7. Description:

    Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $109
    Qty:
    Pack:
    25mg
    Price:
    $250
    Qty:
  8. Pack:
    10mg
    Price:
    $75
    Qty:
    Pack:
    50mg
    Price:
    $305
    Qty:
  9. Forskolin (HB1348)

    4  Reviews
    Top Reviews:
    100% of 100
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    Description:

    Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $124
    Free trial
    Qty:
    Pack:
    50mg
    Price:
    $523
    Qty:
  10. IBMX (HB3000)

    Description:

    Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.

    Purity:

    >98%

    Pack:
    100mg
    Price:
    $48
    Qty:
    Pack:
    500mg
    Price:
    $134
    Qty:
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